863 Blocking the LFA-1 signaling pathway reverses alopecia areata in C3H/HeJ mice
نویسندگان
چکیده
Alopecia areata (AA) is caused by T cell-mediated autoimmune attack of the hair follicle. Therefore, inhibition lymphocyte migration and pathogenic activity represents an attractive therapeutic approach in treatment lymphocyte-mediated diseases, including AA. The function antigen-1 (LFA-1) receptor signaling pathway plays a crucial role cell activation, cells to target tissues formation classical cytolytic immune synapse. We previously showed that intercellular adhesion molecule 1(ICAM-1), one major ligands for LFA-1, upregulated lesional skin both human patients C3H/HeJ mice with observed CD44+CD8+effector/memory expressed high levels LFA-1 within draining lymph nodes as well AA skin. Here, we investigated using mice, found blockade either anti-LFA-1 or anti-ICAM-1 mAbs prevented development grafted mice. Immunohistochemical staining biopsies show anti-LFA-1- anti-ICAM-1-treated have striking decrease infiltration together reduced expression AA-associated markers (MHC-I MHC-II). Furthermore, not only CD44+CD8 +effector/memory into skin, but also led enrichment Tregs nodes. To limit systemic exposure, topically treated lifitegrast, small antagonist lifitegrast was effective reversal Taken together, demonstrated activation AA, achieved local topical delivery. Our results invite further clinical investigation treatment.
منابع مشابه
Alopecia areata.
n engl j med 367;3 nejm.org july 19, 2012 279 methacin should be used in addition to pancre atic stents in highrisk patients. However, post hoc analysis of our trial suggests that indometha cin may obviate the need for prophylactic pan creatic stent placement (unpublished data), and we therefore agree with Baron et al. that com parative effectiveness studies of indomethacin and pancreatic ...
متن کاملAlopecia areata.
Alopecia areata is a frequent cause of hair loss. The origin of disease is not fully understood. However there are indications for a T-cell mediated autoimmune process. Genetic, immunologic and psychologic factors are important for the outbreak of disease. Most patients show localized patches of acute hair loss, where regrowth is observed spontaneously or with simple topical treatment within fe...
متن کاملEye involvement in Alopecia Areata
Background: Alopecia areata is a patchy hair loss that may occur in any hair bearing area on the body. There are many reports of ocular abnormalities such as lens and retinal changes in alopecia areata. Objective: To evaluate ocular alterations in alopecia areata with regard to the lens and retina. Patients & Methods: Seventy three patients with alopecia areata including 34 males and 39 f...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.877